Modulatory Effect of Human Immunodeficiency Virus on Circulating p53, miR-21, and miR-125b: Any Diagnostic Implication?

Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role HIV in carcinogenesis, this study evaluated levels normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) upregulated tumor suppressors (miR-let-7b, miR-125b, miR-143, miR-145, p53 expression) associated with serum living (HIV+) without (HIV. Method: This case-control included 173 women; confirmed HIV+ (n = 103) HIV− 70). Serum miRNAs were determined using reverse transcriptase PCR. t-test Pearson’s correlation analyses carried out on generated data. Result: A higher level miR-21 was observed among compared their counterpart (p 0.028), whereas lower miR-125, gene p 0.050 0.049, respectively. Significant direct relationships between other < 0.05) women. Conclusion: revealed that contributes carcinogenesis by modulating circulating miR-21, p53, miR-125b. It suggests these biomarkers could be used high cancer.